Pentosan polysulfate decreases myocardial expression of the extracellular matrix enzyme ADAMTS4 and improves cardiac function in vivo in rats subjected to pressure overload by aortic banding.
| Author | |
| Abstract |
:
We hypothesized that cleavage of the extracellular matrix (ECM) proteoglycans versican and aggrecan by ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) proteases, which contributes to stress-induced ECM-reorganization in atherogenesis and osteoarthritis, also play a role in heart failure development. |
| Year of Publication |
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0
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| Journal |
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PloS one
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| Volume |
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9
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| Issue |
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3
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| Number of Pages |
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e89621
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| Date Published |
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2014
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| URL |
:
https://dx.plos.org/10.1371/journal.pone.0089621
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| DOI |
:
10.1371/journal.pone.0089621
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| Short Title |
:
PLoS One
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| Download citation |
